PRI KUHAJU HRANE NASTAJAJO NOVE SNOVI — 3 del

Alois Kolar. B.HSc.

(60) Maier, S.F. et al, The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM. Behav. Neurosci. 1995 / 109 (4) / 759-766. , Fanselow, M.S. et al, The benzodiazepine inverse agonist DMCM as an unconditional stimulus for fear-induced analgesia : implications for the role of GABAA receptors in fear-related behaviour. Behav. Neurosci. 1992 / 106 (2) / 336-344. , Cutler, M.G. et al, Effects of the benzodiazepine receptor inverse agonist, DMCM, on the behaviour of mice : an ethopharmacological study. Neuropharmacology 1991 / 30 (12A) / 1255-1261.
(61) Arora, P.K. et al, Suppression of cytotoxic T lymphocyte (CTL) activity by FG7142, a benzodiazepine receptor 'inverse agonist'. Immunopharmacology 1991 / 21 (2) / 91-97. , Petitto, J.M. et al, Suppression of natural killer cell activity by FG7142, a benzodiazepine receptor inverse agonist. Brain. Behav. Immun. 1989 / 3 (1) / 39-46. , Arora, P.K. et al, Suppression of the immune response by benzodiazepine receptor inverse agonists. J. Neuroimmunol. 1987 / 15 (1) / 1-9.
(62) Marescaux, C. et al, Bidirectional effects of the beta-carbolines in rats with spontaneous petit mal-like seizures. Brain. Res. Bull. 1987 / 19 (3) / 327-335.
(63) Jensen, L.H. et al, Bidirectional effects of beta-carbolines and benzodiazepines on cognitive processes. Brain. Res. Bull. 1987 / 19 (3) 359-364.
(64) Garginlo, P.A. et al, Is inhibition by diazepam and beta-carbolines of estrogen-induced luteinizing hormone secretion related to sedative effects ? Pharmacol. Biochem. Behav. 1991 / 40 (2) / 335-338.
(65) Kreeger, T.J. et al, Diazepam-induced feeding in ceptive grey wolves (Canis Lupus). Pharmacol. Biochem. Behav. 1991 / 39 (3) / 559-561. , Cooper, S.J. ,Hyperphagic and anorectic effects of beta-carbolines in a palatable food consumption test : comparisons with triazolam and quazepam. Eur. J. Pharmacol. 1986 / 120 (3) / 257-265.(158) Cooper, S.J. et al, Benzodiazepine receptor ligands and the consumption of highly palatable diet in non-deprived male rats. Psychopharmacology (Berl.) 1985 / 86 (3) / 348-355.
(66) Duka, T. et al, Human studies on the benzodiazepine receptor antagonist beta-carboline ZK93426 : antagonism of lormetazepam's psychotropic effects. Psychopharmacology (Berl.) 1988 / 95 (4) / 463-471. , Dorow, R. et al, Clinical perspectives of beta-carbolines from first studies in humans. Brain. Res. Bull. 1987 / 19 (3) / 319-326.
(67) Duka, T. et al, Effects of ZK93,426, a beta-carboline benzodiazepine receptor antagonist on night sleep pattern in healthy male volunteers. Psychopharmacology (Berl.) 1995 / 117 (2) / 178-185.
(68) File, S.E. et al, Actions of the beta-carboline ZK93426 in an animal test of anxiety and the holeboard : interactions with Ro15-1788. J. Neural. Transm. 1986 / 65 (2) / 103-114.
(69) Papavergou, E. et al, The evaluation in the ames test of the mutagenicity of tetrahydro-beta-carboline-3-carboxylic acids from smoked foods. Food. Addit. Contam. 1992 / 9 (2) / 183-187.
(70) Huttunen, P. et al, Anatomical localization in hippocampus of tetrahydro-beta-carboline-induced alcohol drinking in rat. Alcohol 1987 / 4 (3) / 181-187.
(71) Wible, J.H. et al, Cardiovascular effects of beta-carbolines in conscious rats. Hypertens. Res. 1996 / 19 (3) / 161-170.
(72) Rovescalli, A.C. et al, Endocrine effects of 5-methoxytryptoline, 5-hydrotryptoline and tryptoline, putative modulators of rat serotonergic system. J. Endocrinol. Invest. 1987 / 10 (1) / 65-72.
(73) De Deyn, P.P. et al, Epilepsy and the GABA-hypothesis ,a brief revieuw and some examples. Acta. Neurol. Belg. 1990 / 90 (2) / 65-81. , Smythe, G.A. et al, Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline and yohimbine on hypothalamic monoamine status and pituitary hormone release in rats. Aust. J. Biol. Sci. 83 / 36 (4) / 379-386.
(74) Wettstein, J.G. et al, Distinctive behavioral effects of the pyrazoloquinoline CGS8216 in squirrel monkeys. Pharmacol. Biochem. Behav. 1988 / 29 (4) / 741-745.
(75) Pellow, S. et al, The effects of putative anxiogenic compounds (FG7142, CGS8216 and Ro15-1788) on the rat corticosterone response. Physiol. Behav. 1985 / 35 (4) / 587-590.
(76) Deckert, J. et al, CGS8216 treatment decreases central-type benzodiazepine receptors in rat brain. Eur. J. Pharmacol. 1987 / 142 (3) / 457-460.
(77) Turteltaub ,K.W. et al, MeIQx-DNA adduct formation in rodent and human tissues at low doses. Mutat. Res. 1997 / 376 (1-2) / 243-252.
(78) Hatch, F.T. et al, Quantitative structure-activity (QSAR) relationships of mutagenic aromatic and heterocyclic amines. Mutat. Res. 1997 / 376 (1-2) / 87-96. , Blowers, L. et al, Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County. Cancer Causes Control 1997 / 8 (1) / 5-12. , Barrett, J.H. et al, Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England. Cancer Causes Control 1998 / 9 (2) / 153-159.
(79) Wang, C.J. et al, Promotional effect of N-nitroso-N-(3keto-1,2-butanediol)-3'-nitrotyramine (a nitrosated Maillard reaction product) in mouse fibroblast cells. Fd. Chem. Toxicol. 1998 / 36 (8) / 631-636. , Tseng, T.H. et al, Tumor promoting effect of N-nitroso-N-(2-hexanonyl)-3'-nitrotyramine (a nitrosated Maillard reaction product) in benzo(a)pyrene-initiated mouse skin carcinogenesis. Chem. Biol. Interact. 1998 / 115 (1) / 23-38. , De Stefani, E. et al, Dietary nitrosamines ,heterocyclic amines ,and risk of gastric cancer a case-controle study in Uruguay. Nutr. Cancer 1998 / 30 (2) / 158-162. , Pfau, W. et al, Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido(2,3-b)indole (AalphaC). Chem. Res. Toxicol. 1997 / 10 (10) / 1192-1197. , Herneaz, J. et al, Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ : studies of enzyme inhibition, molecular complex formation ,and degredation / scavenging of the active metabolites. Environ. Mol. Mutagen. 1997 / 30 (4) / 468-474. , Kemmerling, W., Toxicity of Palicourea marcgravii : combined effects of fluoracetate, N-methyltyramine and 2-methyl-tetrahydro-beta-carboline. Z. Naturforsch. (C) 1996 / 51 (1-2) / 59-64. , Hiramoto, K. et al, Induction of DNA recombination by activated 3-amino-1-methyl-5H-pyrido(4,3-b)indole. Jpn. J. Cancer Res. 1995 / 86 (2) / 155-159.
(80) Sugimura, T. et al, Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods. Natl. Cancer Inst. Monogr. 1981 / 58 / 27-33.
(81) Raza, H. et al, Metabolism of 2-amino-alpha-carboline. A food borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. Drug. Metab. Dispos. 1996 / 24 (4) / 395-400. , Yoo, M.A. et al, Mutagenic potency of heterocyclic amines in the Drosophila wing spot test and its correlation to carcinogenic potency. Jpn. J. Cancer Res. 1985 / 76 (6) / 468-473.
(82) Pfau, W. et al, Characterization of the major DNA adduct formed by the food mutagen 2-amino-3-methyl-9H-pyrido(2,3-b)indole (MeAalphaC) in primary rat hepatocytes. Carcinogenesis 1996 / 17 (12) / 2727-2732. , Pfau, W. et al, Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo(4,5-b)prydine (PhIP) and 2-amino-3-methyl-9H-pyrido(2,3-b)indole (MeAalphaC). Mutat. Res. 1997 / 378 (1-2) / 13-22.
(83) Ashida, H. et al, Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes. Biosci. Biotechnol. Biochem. 1998 / 62 (11) / 2283-2287.
(84) Sasaki, Y.F. et al, In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse. Mutat. Res. 1997 / 395 (1) / 57-73. , Sugimura,T. et al, Mutagens in food. Journal of Agriculture and Food Chemistry 1995 / 43 / 404-414. , Manabe, S. et al, Carcinogenic tryptophan pyrolysis products in the environment. J. Toxicol. Sci. 1991 / 16 (suoppl.1) / 63-72.
(85) Higashimoto, M. ,Inhibitory effects of citrus fruits on the mutagenicity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid treated with nitrite in the presence of ethanol. Mutat. Res. 1998 / 415 (3) / 219-226. , Papavergou, E. et al, The evaluation in the Ames test of the mutagenicity of tetrahydro-beta-carboline-3-carboxylic acids from smoked foods. Food. Addit. Contam. 1992 / 9 (2) / 183-187. , Wakabayashi, K. et al, Presence of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acids and tyramine as precursers of mutagens in soyasauce after nitrite treatment. IARC Sci. Publ. 1984 / 57 / 17-24.
(86) Hammons, G.J. et al, Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. Nutr. Cancer 199 / 33 (1) / 46-52.
(87) Sabbioni, G. et al, Hemoglobin binding of bicyclic aromatic amines. Chem. Res. Toxicol. 1998 / 11 (5) / 471-483.
(88) Williams, G.M. et al, Inhibition by acetaminophen of intestinal cancer in rats induced by an aromatic amine similar to food mutagens. Eur. J. Cancer Prev. 1997 / 6 (4) / 357-362.
(89) Pence, B.C. et al, Feeding of a well-cooked beef diet containing a high heterocyclic amine content enhances colon and stomach carcinogenesis in 1,2-dimethylhydrazine-treated rats. Nutr. Cancer 1998 / 30 (3) / 220-226.
(90) Hiramoto, K. et al, Induction of DNA recombination by activated 3-amino-1-methyl-5H-pyrido(4,3-b)indole. Jpn. J. Cancer Res. 1995 / 86 (2) / 155-159.
(91) Ojala, W.H. et al, Heterocyclic N-acetoxyarylamines, models for the putative ultimate carcinogens of aromatic amines : 2-acetoxyamino-5-phenylpyridine and 2-acetoxyaminopyridine. Acta. Cristallogr. C. 1997 / 53 (pt 5) / 634-637.
(92) Koch, W.H. et al, Specificity of base substitution mutations induced by the dietary carcinogens 2-amino-1methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) and 2-amino-3-methylimidazo(4,5-f)quinoline (IQ) in Salmonella. Environ. Mol. Mutagen 1998 / 31 (4) / 327-332. , Nagao, M. et al, Genetic changes induced by heterocyclic amines. Mutat. Res. 1997 / 376 (1-2) / 161-167. , Thompson, L.H. et al, Comparative genotoxic effects of the cooked-food-related mutagens Trp-P-2 and IQ in bacteric and cultured mammalian cells. Mutat. Res. 1983 / 117 (3-4) / 243-257.
(93) Broschard, T.H. et al, Mutagenic specificity of the food mutagen 2-amino-3-methylimidazo(4,5-f)quinoline in Escheria coli using the yeast URA3 gene as a target. Carcinogenesis 1998 / 19 (2) / 305-310.
(94) Waldren, C.A. et al, Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the si locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures. Mutat. Res. 1999 / 425 (1) / 29-46. , Okonogi, H. et al, Agreement of mutational characteristics of heterocyclic amines in lacl of the Big Blue mouse with those in tumor related genes in rodents. Carcinogenesis 1997 / 18 (4) / 745-748.
(95) Sasaki, Y.F. et al, Colon specific genotoxicity of heterocyclic amines detected by themodified alkaline single cell gel electrophoresis assay of multiple mouse organs. Mutat. Res. 1998 / 414 (1-3) / 9-14. , Grivas, S., Synthetic roots to the food carcinogen 2-amino-3,8-dimethylimidazo(4,5-f)quinozaline (8-MeIQx) and related compounds. Princess Takamatsu Symp. 1995 / 23 / 1-8.
(96) Schut, H.A. et al, DNA adducts of heterocyclic amine food mutagens : implications for mutagenesis and carcinogenesis. Carcinogenesis 1999 / 20 (3) / 353-368.
(97) Frandsen, H. ,Excretion of DNA adducts of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and and 2-amino-3,4,8-trimethylimidazo(4,5-f)quinoxaline, PhIP-dg, PhIP-DNA and DiMeIQx-DNA from rat. Carcinogenesis 1997 / 18 (8) / 1555-1560. , Knize, M.G. et al, Identification of the mutagenic quinoxaline isomers from fried ground beef. Mutat. Res. 1987 / 178 (1) / 25-32.
(98) Solyakov, A. et al, Heterocyclic amines in process flavours, process flavour ingredients, bouillon concentrates and a pan residue. Food Chem. Toxicol. 1999 / 37 (1) / 1-11. , Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233. , Stavric, B. et al, Mutagenic heterocyclic aromatic amines (HAA's) in 'processed food flavour' samples. Food Chem. Toxicol. 1997 / 35 (2) / 185-197. , Wakabayashi, K. et al, Human exposure to mutagenic / carcinogenic heterocyclic amines and comutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259. , Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194. , Gross, G.A. et al, Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grilled scrapings. Carcinogenesis 1993 / 14 (11) / 2313-2318. , Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209.
(99) Becher, G. et al, Isolation and identification of mutagens from a fried Norwegian meat product. Carcinogenesis 1988 / 9 (2) / 247-253.

Se nadaljuje…